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2,4-Dichlorobenzyl bromide → 5-tert-Butyl-3-(2,4-dichloro-benzyl)-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichlorobenzyl bromide | HCID 10988373 | — |
| 反応物 | 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558205 | — |
| 反応物 | HCID 178441789 | HCID 178441789 | — |
| 生成物 | 5-tert-Butyl-3-(2,4-dichloro-benzyl)-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558209 | — |
反応手順
In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 1-(bromomethyl)-2,4-dichlorobenzene and isolated as colorless gum (6.5 mg, 36%). MS (m/e): 441.3 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741906B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-1ebf1051b9934782b80e503a4410665f |
| 出典メモ | uspto-grants-2014_06 |