5-(chloromethyl)-1-methyl-1H-1,2,3,4-tetrazole → 5-tert-Butyl-3-(1-methyl-1H-tetrazol-5-ylmethyl)-7-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

HRID 400948ノート

反応式

HRID 400948 の反応式
C(C1N=C(N2CCC(F)(F)C2)[C:8]2[N:13]=[N:12][N:11]([CH2:14]C)[C:9]=2[N:10]=1)(C)(C)C.[C:23]([C:27]1[N:28]=[C:29]([N:36]2[CH2:42][C:38]3([CH2:41][O:40][CH2:39]3)[CH2:37]2)[C:30]2[N:35]=[N:34][NH:33][C:31]=2[N:32]=1)([CH3:26])([CH3:25])[CH3:24].ClCC1N(C)N=NN=1>>[C:23]([C:27]1[N:28]=[C:29]([N:36]2[CH2:37][C:38]3([CH2:39][O:40][CH2:41]3)[CH2:42]2)[C:30]2[N:35]=[N:34][N:33]([CH2:8][C:9]3[N:11]([CH3:14])[N:12]=[N:13][N:10]=3)[C:31]=2[N:32]=1)([CH3:26])([CH3:24])[CH3:25]

参加物

4

反応物 3

HCID 122050865-(chloromethyl)-1-methyl-1H-1,2,3,4-tetrazoleHCID 715582055-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 178441781HCID 178441781、化合物

生成物 1

HCID 866833595-tert-Butyl-3-(1-methyl-1H-tetrazol-5-ylmethyl)-7-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

実験手順

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-Butyl-7-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 5-(chloromethyl)-1-methyl-1H-tetrazole and isolated as white solid. MS (m/e): 371.3 (MH+).

後処理

  1. customisolated as white solid

出典と根拠

ORDレコード
ord-0845bc354a5d4dec8c636f92836a6ed5
出典データセット
uspto-grants-2014_06
特許番号
US08741906B2

反応ノート

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