4-Bromo-1-chloro-2-fluorobenzene → 1-(4-Chloro-3-fluorophenyl)-2-phenylethanone

反応式

ClC1C=C([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)C=C(Cl)C=1.Br[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([F:26])[CH:20]=1>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:20][C:21]=1[F:26]

参加物

反応物 2

HCID 27246904-Bromo-1-chloro-2-fluorobenzene

HCID 27581461-(3,5-Dichlorophenyl)-2-phenylethanone

生成物 1

HCID 27575671-(4-Chloro-3-fluorophenyl)-2-phenylethanone収率 18.2%

実験手順

Prepared following the procedure described in Intermediate 13, starting from 4-bromo-1-chloro-2-fluorobenzene, where the crude product was purified by column chromatography (PE: EtOAc=100:1) to afford Intermediate 16 (200 mg, yield 18.2%).

後処理

customPrepared
customwas purified by column chromatography (PE: EtOAc=100:1)

出典と根拠

ORDレコード: ord-fdea99ed30c54ddc8a71e7b626fbdc86
出典データセット: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08741915B2

反応ノート

読み込み中…

参加物