化工社化工社 化学情報印刷レポート · 研究参考用
N-Methoxy-N-methylnicotinamide → 2-Phenyl-1-pyridin-3-yl-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methoxy-N-methylnicotinamide | HCID 10558996 | — |
| 反応物 | 3,4-Dimethoxy-2-phenylacetophenone | HCID 12336683 | — |
| 反応物 | HCID 178418336 | HCID 178418336 | — |
| 生成物 | 2-Phenyl-1-pyridin-3-yl-ethanone | HCID 4328900 | 19% |
反応手順
Followed the procedure described in Step 2 of Intermediate 7 with N-methoxy-N-methylnicotinamide and benzylmagnesium chloride, where the mixture was stirred for 3 hours. Purification was achieved by column chromatography (PE:EtOAc=5:1) to give Intermediate 31 (110 mg, yield 19%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741915B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-529c2619fe2a41d1bf2b7619d4df34c9 |
| 出典メモ | uspto-grants-2014_06 |