Potassium tert-butoxide → 2-Isopropyl-6-nitro-1H-indole

HRID 40119ノート

反応式

HRID 40119 の反応式
[CH3:1][CH:2]([CH3:20])[C:3]#[C:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[NH:14]C(=O)CCC.CC([O-])(C)C.[K+]>CN1C(=O)CCC1.CCOC(C)=O>[CH:2]([C:3]1[NH:14][C:6]2[C:5]([CH:4]=1)=[CH:10][CH:9]=[C:8]([N+:11]([O-:13])=[O:12])[CH:7]=2)([CH3:20])[CH3:1]

参加物

5

反応物 2

HCID 23665647Potassium tert-butoxideHCID 59762443N-(2-(3-Methylbut-1-ynyl)-5-nitrophenyl)butyramide2 回

生成物 1

HCID 597623802-Isopropyl-6-nitro-1H-indole

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
70 °C

実験手順

To a solution of N-(2-(3-methylbut-1-ynyl)-5-nitrophenyl)butyramide (Compound 119, 900 mg, 3.29 mmol) in NMP (10 ml) was added KOt-Bu (552 mg, 4.94 mmol) and the mixture was stirred at 70° C. for 16 h, cooled to room temperature, diluted with EtOAc, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→25% EtOAc-hexanes) to yield the title compound.

後処理

  1. temperaturecooled to room temperature
  2. washwashed with brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by chromatography on silica gel (0→25% EtOAc-hexanes)

出典と根拠

ORDレコード
ord-9930116e41c24842af7e9236d560efb7
出典データセット
uspto-grants-2013_09
特許番号
US08524917B2

反応ノート

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