Methyl 2-chloro-4-(hydroxymethyl)benzoate → Methyl 2-chloro-4-formylbenzoate

HRID 401206ノート

反応式

HRID 401206 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]([CH2:12][OH:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>ClCCl.[O-2].[Mn+2]>[Cl:1][C:2]1[CH:11]=[C:10]([CH:12]=[O:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

参加物

4

反応物 1

HCID 19780655Methyl 2-chloro-4-(hydroxymethyl)benzoate

生成物 1

HCID 57461225Methyl 2-chloro-4-formylbenzoate収率 62.2%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

反応条件

温度
27 °C

実験手順

A mixture of methyl 2-chloro-4-(hydroxymethyl)benzoate (350 mg, 1.7 mmol) in and manganese oxide (756 mg, 30.9 mmol) in dichloromethane (10 mL) was stirred at 27° C. for 6 hours. The mixture was filtered and evaporated in vacuo to give Intermediate 75 (210 mg, 61%).

後処理

  1. filtrationThe mixture was filtered
  2. customevaporated in vacuo

出典と根拠

ORDレコード
ord-418dcfbc5d2947c8a95f87c45bc11202
出典データセット
uspto-grants-2014_06
特許番号
US08741915B2

反応ノート

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