関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | 3-Aminocyclohex-2-en-1-one | HCID 78892 | — |
| 生成物 | diethyl N-(3-oxo-1-cyclohexen-1-yl)-aminomethylenemalonate | HCID 12877078 | 90% |
反応手順
A mixture of 3-amino-cyclohex-2-enone (3.3 g, 29.7 mmol) and diethyl 2-(ethoxymethylene)malonate (6.7 g, 31.2 mmol) was stirred at 130° C. for 4 h. The reaction mixture was concentrated under reduced pressure and the resulting oil was purified by column chromatography (silica gel, ethyl acetate) to give 2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester (7.5 g, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08741925B2 |
|---|
| 出典データセット | uspto-grants-2014_06 |
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| ORD ID | ord-f834384df36a40938616eb219eee5085 |
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| 出典メモ | uspto-grants-2014_06 |
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