Dimethylformamide → [2-(5-Fluoro-2,4-dinitro-phenyl)-vinyl]-dimethyl-amine

HRID 401275

反応式

HRID 401275 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CO[CH:17]([N:20]([CH3:22])[CH3:21])OC.CN(C=O)C>O>[F:1][C:2]1[C:3]([N+:12]([O-:14])=[O:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH:8]=[CH:17][N:20]([CH3:22])[CH3:21])[CH:7]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 78373Dimethylformamide dimethyl acetalHCID 5207051-Fluoro-5-methyl-2,4-dinitrobenzene

生成物 1

HCID 57060726[2-(5-Fluoro-2,4-dinitro-phenyl)-vinyl]-dimethyl-amine収率 63%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 1-fluoro-5-methyl-2,4-dinitro-benzene (10 g, 50 mmol), dimethoxymethyl-dimethylamine (11.9 g, 100 mmol) and DMF (50 mL) was heated at 100° C. for 4 h. The solution was cooled and poured into water. The red precipitate was collected via filtration, washed with water adequately and dried to give [2-(5-fluoro-2,4-dinitro-phenyl)-vinyl]-dimethyl-amine (8 g, 63%).

後処理

  1. temperatureThe solution was cooled
  2. filtrationThe red precipitate was collected via filtration
  3. washwashed with water adequately
  4. customdried

出典と根拠

ORDレコード
ord-6f6e3b0b9c264bdc91c22d4cc7f9a5cb
出典データセット
uspto-grants-2014_06
特許番号
US08741925B2

関連ノート

読み込み中…