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Bromine → 1-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 1-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one | HCID 27673 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 1-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 721847 | 115.7% |
反応手順
To a solution of 1-(2,3-dihydro-indol-1-yl)-ethanone (58.0 g, 0.36 mol) in acetic acid (3000 mL) was added Br2 (87.0 g, 0.54 mol) at 10° C. The mixture was stirred at room temperature for 4 h. The precipitate was collected via filtration to give crude 1-(5-bromo-2,3-dihydro-indol-1-yl)-ethanone (100 g, 96%), which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741925B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-578f1f7d1b154573944356fb85b1bf51 |
| 出典メモ | uspto-grants-2014_06 |