5-Methoxy-2-(3-methylbut-1-ynyl)aniline → 2-Isopropyl-6-methoxy-1H-indole
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:10]#[C:11][CH:12]([CH3:14])[CH3:13])=[C:7]([CH:9]=1)[NH2:8]>CN(C=O)C.[Cu]I>[CH:12]([C:11]1[NH:8][C:7]2[C:6]([CH:10]=1)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:9]=2)([CH3:14])[CH3:13]参加物
4
反応条件
- 温度
- 160 °C
実験手順
To a solution of 5-methoxy-2-(3-methylbut-1-ynyl)aniline (Compound 135, 1.8 g, 9.5 mmol) in DMF (20 ml) was added CuI (101 mg, 0.53 mmol). The reaction was stirred at 160° C. for 1.5 h. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (0→25% EtOAc-hexanes) to yield the title compound as a brownish red solid.
後処理
- customThe solvent was removed in vacuo
- customthe residue was purified by chromatography on silica gel (0→25% EtOAc-hexanes)
出典と根拠
- ORDレコード
- ord-d729692a87884250a6619b9f8339b84e
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524917B2
反応ノート
読み込み中…