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Hydrogen Bromide → 6-Cyclobutoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Bromocyclobutane | HCID 78110 | — |
| 反応物 | 3,4-Difluorobenzylamine | HCID 123572 | — |
| 反応物 | 3-(Bromomethyl)pyridine | HCID 245934 | — |
| 反応物 | 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde | HCID 59762309 | — |
| 生成物 | 6-Cyclobutoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide | HCID 59762358 | — |
反応手順
The title compound was prepared from 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137), 3-(bromomethyl)pyridine.HBr, 3,4-difluorobenzylamine, and cyclobutyl bromide by, in order, General Procedure J, General Procedure K, General Procedure C, General Procedure L, and General Procedure N.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524917B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-55f9e6fabcba425ab1c1072f1aee8be9 |
| 出典メモ | uspto-grants-2013_09 |