Ammonium Hydroxide → (2-Aminopyridin-3-yl)(6-chloro-3-(trifluoromethyl)pyridin-2-yl)methanone
反応式
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([C:10]2[C:11](F)=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])[C:5]([C:17]([F:20])([F:19])[F:18])=[CH:4][CH:3]=1.[OH-].[NH4+:22]>>[NH2:22][C:11]1[C:10]([C:8]([C:6]2[C:5]([C:17]([F:20])([F:19])[F:18])=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=2)=[O:9])=[CH:15][CH:14]=[CH:13][N:12]=1参加物
3
実験手順
A mixture of (6-chloro-3-(trifluoromethyl)pyridin-2-yl)(2-fluoropyridin-3-yl)methanone (2.27 g, 7.452 mmol) and a saturated aqueous solution of ammonium hydroxide (20 mL, 513.6 mmol) was heated to 70° C. for 18 hours. The mixture was cooled down to room temperature and the resulting solid was filtered, washed with water and dried under vacuum to give the title compound as a pale yellow solid (2.12 g, 94% yield).
後処理
- filtrationthe resulting solid was filtered
- washwashed with water