2-Chloro-3-nitropyridine → 2-Methoxy-3-nitropyridine

HRID 401584

反応式

HRID 401584 の反応式
[CH3:1][O-:2].[Na+].Cl[C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][N:6]=1>CO>[CH3:1][O:2][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][N:6]=1

参加物

4

反応物 2

HCID 796132-Chloro-3-nitropyridineHCID 10942334Sodium Methoxide

生成物 1

HCID 2532192-Methoxy-3-nitropyridine収率 90%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A suspension of sodium methoxide (40.5 g, 0.750 mol) in 200 mL of methanol was slowly added to a solution of 2-chloro-3-nitro-pyridine (79.3 g, 0.500 mol) in 800 mL of methanol at 0° C. The reaction mixture was stirred for 4 hours and then poured into 1000 g of ice. The resulting precipitate was filtered, washed with water, and dried to give 2-methoxy-3-nitro-pyridine (70. g, 0.45 mmol, 90%) as a white solid.

後処理

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-eb94a1b61527486d83644ea944d2140a
出典データセット
uspto-grants-2014_06
特許番号
US08741939B2

関連ノート

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