Water → HCID 59625812、化合物

HRID 401706ノート

反応式

HRID 401706 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:20](OC)(OC)OC.O>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[N:1]=[CH:20]2)=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 962WaterHCID 9005Trimethyl orthoformateHCID 59625705HCID 59625705、化合物

生成物 1

HCID 59625812HCID 59625812、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 60d (0.18 g, 0.693 mmol) and trimethyl orthoformate (0.7 mL, 6.39 mmol) in DMF (2 mL) was refluxed for 5 h and then cooled to room temperature. Water was added to the mixture. The resulting solid was filtered, washed, with water, and dried. The crude product 60e was used in the next reaction without purification. MS m/z (M+H+) 271.1.

後処理

  1. temperaturewas refluxed for 5 h
  2. filtrationThe resulting solid was filtered
  3. washwashed, with water
  4. customdried
  5. customThe crude product 60e was used in the next reaction without purification

出典と根拠

ORDレコード
ord-a1119f9447de4f6da1e62a762268de44
出典データセット
uspto-grants-2014_06
特許番号
US08741887B2

反応ノート

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