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1-(4-Trifluoromethylphenyl)Ethylamine → 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]-N-[1-[4-(trifluoromethyl)phenyl]ethyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Trifluoromethylphenyl)Ethylamine | HCID 2782449 | — |
| 反応物 | 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]benzoic acid | HCID 57732214 | — |
| 生成物 | 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]-N-[1-[4-(trifluoromethyl)phenyl]ethyl]benzamide | HCID 57732003 | — |
反応手順
The title compound was prepared from 4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzoic acid (Preparation 29) and 1-[4-(trifluoromethyl)phenyl]ethanamine following the procedure described in Example 309. The reaction mixture was extracted from saturated sodium hydrogen carbonate into DCM and the crude product purified by preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741934B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-4afe0ed5471e4f02bfc3311d06f68277 |
| 出典メモ | uspto-grants-2014_06 |