HCID 23055952、化合物 → HCID 67254977、化合物
反応式
[CH2:1]([NH:4][C@@H:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH:6]1[Br:14])[CH:2]=[CH2:3].Br.CC(O)C>CC(OC)(C)C>[BrH:14].[CH2:1]([NH:4][C@@H:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH:6]1[Br:14])[CH:2]=[CH2:3]参加物
4
反応条件
- 温度
- 7.5 °C
実験手順
The obtained N-2-Propene-1-yl-2-bromo-(R)-aminoindan (5 g) in 100 ml of MTBE was added to 10 ml of 10% HBr/IPA solution and the reaction mixture was stirred at 5-10° C. for 30 min. The precipitated solid was filtered, washed with MTBE and dried to give 8.7 g of N-2-Propene-1-yl-2-bromo-(R)-aminoindan hydrobromide (90% yield). Mass spectrum: [M+1]+: 252
後処理
- filtrationThe precipitated solid was filtered
- washwashed with MTBE
- customdried
出典と根拠
- ORDレコード
- ord-68e3db8ba0724da18daec6b71b19523a
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08741962B2
反応ノート
読み込み中…