Ammonia → Tert-butyl 4-carbamoyl-4-fluoropiperidine-1-carboxylate

HRID 402071ノート

反応式

HRID 402071 の反応式
C([O:3][C:4]([C:6]1([F:19])[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=O)C.[NH3:20]>CO>[C:15]([O:14][C:12]([N:9]1[CH2:10][CH2:11][C:6]([C:4](=[O:3])[NH2:20])([F:19])[CH2:7][CH2:8]1)=[O:13])([CH3:18])([CH3:17])[CH3:16]

参加物

4

反応物 2

HCID 222AmmoniaHCID 21306965Ethyl N-Boc-4-fluoropiperidine-4-carboxylate

生成物 1

HCID 46942209Tert-butyl 4-carbamoyl-4-fluoropiperidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-Fluoro-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (1.8 mmol, 0.5 g) was taken in 7M NH3 in MeOH (5 mL) and stirred at room temperature for 12 h in a sealed vial. All volatiles were removed under reduced pressure to provide 4-carbamoyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester as white solid.

後処理

  1. customAll volatiles were removed under reduced pressure

出典と根拠

ORDレコード
ord-bbe6e355e58e4d0bba1906dc49aa36b8
出典データセット
uspto-grants-2014_06
特許番号
US08741900B2

反応ノート

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