5-Bromoisatoic Anhydride → 6-bromoquinazolin-4-ol

HRID 40239ノート

反応式

HRID 40239 の反応式
[Br:1][C:2]1[CH:13]=[C:6]2[C:7](O[C:10](=O)[NH:11][C:5]2=[CH:4][CH:3]=1)=[O:8].C([O-])(=O)C.C(N)=[NH2+:19]>CC(O)C>[Br:1][C:2]1[CH:13]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:10][NH:19][C:7]2=[O:8]

参加物

4

反応物 2

HCID 2885615-Bromoisatoic AnhydrideHCID 10285782Iminomethanaminium acetate

生成物 1

HCID 1354449056-bromoquinazolin-4-ol

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A solution of 5-bromoisatoic anhydride (5.0 g, 21 mmol) and formamidinium acetate (2.2 g, 21 mmol) in 60 mL of i-PrOH was heated at reflux for 10 hours. The reaction mixture was cooled to rt and the white solid was collected by filtration. The white solid was washed with small amount of i-PrOH and dried in air to give desired product 6-bromoquinazolin-4(3H)-one. MS (ESI, pos. ion) m/z: 224.9 (M+1).

後処理

  1. temperatureat reflux for 10 hours
  2. filtrationthe white solid was collected by filtration
  3. washThe white solid was washed with small amount of i-PrOH
  4. customdried in air

出典と根拠

ORDレコード
ord-153754fc21ba4e269689d52dcd513510
出典データセット
uspto-grants-2013_09
特許番号
US08524900B2

反応ノート

読み込み中…