HCID 178472741、化合物 → HCID 178525874、化合物
反応式
C([O:3][C:4](=[O:26])[CH2:5][NH:6][C@H:7]1[CH2:12][CH2:11][C@@H:10]([O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][C:23]=2[Cl:24])[C:20](=[O:25])[NH:19][CH:18]=[CH:17]3)[CH2:9][CH2:8]1)C>CO>[Cl:24][C:23]1[CH:22]=[C:21]2[C:16]([CH:17]=[CH:18][NH:19][C:20]2=[O:25])=[CH:15][C:14]=1[O:13][C@@H:10]1[CH2:9][CH2:8][C@H:7]([NH:6][CH2:5][C:4]([OH:26])=[O:3])[CH2:12][CH2:11]1参加物
3
実験手順
185 mg of [4-(7-chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-cis-cyclohexylamino]-acetic acid ethyl ester (23, crude product) were dissolved in 2 ml methanol. After adding 2 ml of 2 N NaCO3-solution, the solution was stirred at room temperature for 1.5 h. The solvent was evaporated in vacuo and the residue was purified by preparative HPLC, which delivers the title compound as trifluoro acetate. Rt=0.91 min (Method B). Detected mass: 351.3 (M+H+).
後処理
- customThe solvent was evaporated in vacuo
- customthe residue was purified by preparative HPLC, which