Hydrochloric Acid → 5-Aminocyclooctan-1-ol

HRID 402545ノート

反応式

HRID 402545 の反応式
Cl.C([Si](C)(C)[O:7][CH:8]1[CH2:15][CH2:14][CH2:13][CH:12]([NH2:16])[CH2:11][CH2:10][CH2:9]1)(C)(C)C>CC(O)C>[NH2:16][CH:12]1[CH2:13][CH2:14][CH2:15][CH:8]([OH:7])[CH2:9][CH2:10][CH2:11]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 592248345-(tert-Butyl-dimethyl-silanyloxy)-cyclooctylamine

生成物 1

HCID 214902395-Aminocyclooctan-1-ol収率 138.6%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

35 mL of 2N aqueous hydrochloric acid were added to a solution of 3.5 g (13.6 mmol) of 5-(tert-butyl-dimethyl-silanyloxy)-cyclooctylamine (59) in 35 mL 2-propanol and the resulting solution was stirred at room temperature overnight. The isopropanol was removed under reduced pressure and the resulting aqueous solution washed with t-butylmethylether. 2.7 g of crude 5-amino-cyclooctanol (60) was obtained by freeze-drying the aqueous layer as a diastereomeric mixture as hydrochloride which was used without further purification. Rt=0.18 min (Method C). Detected mass: 144.2 (M+H+).

後処理

  1. customThe isopropanol was removed under reduced pressure
  2. washthe resulting aqueous solution washed with t-butylmethylether

出典と根拠

ORDレコード
ord-154e3a4420184878b1f60e8dace4cd99
出典データセット
uspto-grants-2014_06
特許番号
US08742116B2

反応ノート

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