関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-Bromo-5-methoxypyridine | HCID 817163 | — |
| 触媒 | Copper Sulfate | HCID 24462 | — |
| 生成物 | 5-Methoxypyridin-3-ylamine | HCID 12703595 | — |
反応手順
3-Bromo-5-methoxypyridine (15 g) was added to a pressure vessel, and CuSO4 (3.9 g) and 25% aq ammonia (150 mL) were added. The reaction mixture was stirred for 4 h at 135° C., then cooled to RT, basified with aqueous NaOH solution, and extracted with CH2Cl2. After evaporation of volatiles, 3-amino-5-methoxypyridine was obtained as yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524900B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-2201f9415fc24aaa9edc6fe64207147c |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
