Hydrochloric Acid → N,N-diethylpiperidin-4-amine dihydrochloride
反応式
[ClH:1].[CH2:2]([N:4]([CH:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)[CH2:5][CH3:6])[CH3:3]>O1CCOCC1>[ClH:1].[ClH:1].[CH2:5]([N:4]([CH2:2][CH3:3])[CH:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)[CH3:6]参加物
4
実験手順
Cooled with ice bath, 4M hydrochloric acid in dioxane (25 mL) was added to tert-butyl 4-(N,N-diethylamino)piperidine-1-carboxylate (6.1 g, 0.024 mol) and the mixture was stirred at ambient temperature for 2 h. The solvent was removed under reduced pressure, and the residue was suspended in diethyl ether, then the precipitate was collected by filtration, washed with diethyl ether and then dried to afford 4-(diethylamino)piperidine dihydrochloride as solid (3.9 g, y. 99%).
後処理
- temperatureCooled with ice bath
- customThe solvent was removed under reduced pressure
- filtrationthe precipitate was collected by filtration
- washwashed with diethyl ether
- customdried
出典と根拠
- ORDレコード
- ord-76f2511540674c5588ae910c92dbea84
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08742113B2
反応ノート
読み込み中…