Potassium Carbonate → 1118915-78-8

HRID 402753

反応式

HRID 402753 の反応式
[P:1](Cl)(=[O:18])([O:10]CC1C=CC=CC=1)[O:2]CC1C=CC=CC=1.C([O:27][C:28]1[CH:33]=[C:32]([O:34]COCC)[C:31]([CH:39]([CH3:41])[CH3:40])=[CH:30][C:29]=1[C:42]1[N:46]([C:47]2[CH:48]=[C:49]3[C:53](=[CH:54][CH:55]=2)[N:52]([CH3:56])[CH:51]=[CH:50]3)[C:45](=[O:57])[N:44](C(OCC2C=CC=CC=2)=O)[N:43]=1)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[P:1]([OH:18])([OH:10])([O:34][C:32]1[CH:33]=[C:28]([OH:27])[C:29]([C:42]2[N:46]([C:47]3[CH:48]=[C:49]4[C:53](=[CH:54][CH:55]=3)[N:52]([CH3:56])[CH:51]=[CH:50]4)[C:45](=[O:57])[NH:44][N:43]=2)=[CH:30][C:31]=1[CH:39]([CH3:41])[CH3:40])=[O:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 4641201(Chloro(phenylmethoxy)phosphoryl)oxymethylbenzeneHCID 67339760HCID 67339760、化合物

生成物 1

HCID 1355659621118915-78-8

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Dibenzyl phosphorochloridate was added to the solution of benzyl 3-(2-(benzyloxy)-4-(ethoxymethoxy)-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxylate and potassium carbonate in acetone. The reaction mixture was stirred at room temperature overnight. After removal of solvent, the reaction mixture was purified by column chromatography to produce pale yellow oil, which was hydrogenated to give the desired.

後処理

  1. customAfter removal of solvent
  2. customthe reaction mixture was purified by column chromatography
  3. customto produce pale yellow oil, which
  4. customto give the

出典と根拠

ORDレコード
ord-ba3528f8eb2a40c6995f3c6584758949
出典データセット
uspto-grants-2014_06
特許番号
US08742133B2

関連ノート

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