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4-Chloro-1-fluoro-2-nitrobenzene → 5-Chloro-2-[3,4-dihydro-1(2H)-quinolinyl]aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-1-fluoro-2-nitrobenzene | HCID 67660 | — |
| 反応物 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 反応物 | N-[2-(2,3-dihydro-1H-indol-1-yl)-5-fluorophenyl]-4-methyl-1-piperazine carboxamide maleate | HCID 70406853 | — |
| 生成物 | 5-Chloro-2-[3,4-dihydro-1(2H)-quinolinyl]aniline | HCID 19624508 | — |
| 生成物 | 10-chloro-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine | HCID 20129108 | — |
| 生成物 | 1-(4-Chloro-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 21297647 | — |
反応手順
Starting with 1,2,3,4-tetrahydroquinoline and 5-chloro-2-fluoronitrobenzene and following the steps of 1a to 1f of Example 2, one may obtain, in sequence, 1-(4-chloro-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-amino-4-chlorophenyl)-1,2,3,4-tetrahydroquinoline, N-[2-{1-(5-chlorophenyl)-1,2,3,4-tetrahydroquinolin-1-yl}]-4-methyl-1-piperazine carboxamide, and 10-chloro-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04723007 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-6a47530caf27464e9ee5adb12b91d28b |
| 出典メモ | uspto-grants-1988_02 |