化工社化工社 化学情報印刷レポート · 研究参考用
HRID 40280作成日：2026年10月23日
tert-Butylsulfinamide, (R)-(+)- → (NZ,R)-N-[(4-bromo-2-chlorophenyl)methylidene]-2-methylpropane-2-sulfinamide
https://huagongshe.com/ja/reaction/40280
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | tert-Butylsulfinamide, (R)-(+)- | HCID 10964479 | — |
| 反応物 | 4-Bromo-2-chlorobenzaldehyde | HCID 14109109 | — |
| 触媒 | Copper Sulfate | HCID 24462 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (NZ,R)-N-[(4-bromo-2-chlorophenyl)methylidene]-2-methylpropane-2-sulfinamide | HCID 57691068 | — |
反応手順
A suspension of 4-bromo-2-chlorobenzaldehyde (1150 mg, 5240 μmol), (r)-(+)-2-methyl-2-propanesulfinamide (1588 mg, 13100 μmol), copper(ii) sulfate (696.4 μl, 15720 μmol) in DCM (10 mL) was stirred at 37° C. for 78 h. Reaction filtered through Celite, and solid washed repeatedly with DCM. Filtrate concentrated then purified on silica (80 g) eluting product with 0>30% of EtOAc/Hex. MS (ESI pos. ion) m/z: 322/324 (MH+). Calc'd exact mass for C11H13BrClNOS: 321/323.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524900B2 |
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| 出典データセット | uspto-grants-2013_09 |
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| ORD ID | ord-4f79440e739e4ef3b2297af9766d349c |
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| 出典メモ | uspto-grants-2013_09 |
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