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Potassium Carbonate → 6-Cyclopropyl-2,2-dimethylchroman-8-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| 反応物 | Potassium cyclopropyltrifluoroborate | HCID 23697338 | — |
| 反応物 | 6-Chloro-2,2-dimethylchroman-8-carbaldehyde | HCID 77230853 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 生成物 | 6-Cyclopropyl-2,2-dimethylchroman-8-carbaldehyde | HCID 77230852 | — |
反応手順
Using essentially the same procedure as Example 5-22, Step 4, Pd(OAc)2 (7.04 mg, 0.03 mmol), X-Phos (29.9 mg, 0.06 mmol), potassium carbonate (434 mg, 3.14 mmol), potassium cyclopropyltrifluoroborate (170 mg, 1.15 mmol) and 6-chloro-2,2-dimethyl-3,4-dihydro-2H-chromene-8-carbaldehyde (235 mg, 1.05 mmol, Example 5-26, Step 3) afforded the desired product as a pale-yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08742110B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-6ccc0aa3f9044d488b96aefe37ec5959 |
| 出典メモ | uspto-grants-2014_06 |