Methyl iodide → Isoflavone

関与物質

反応手順

Prepared according to the general procedure using genistein (300 mg, 1.11 mmol), K2CO3 (307 mg, 2.22 mmol), acetone and MeI (0.139 mL). Purified by flash column chromatography (SiO2, 1% MeOH/CH2Cl2) to afford 15 (70 mg, 22%) as an off-white solid. Analytical data for isoflavone 15: 1H NMR (500 MHz, DMSO) δ 12.96 (s, 1H), 9.62 (s, 1H), 8.41 (s, 1H), 7.39 (d, J=8.5 Hz, 2H), 6.82 (d, J=8.5 Hz, 2H), 6.65 (s, 1H), 6.41 (s, 1H), 3.86 (s, 3H); 13C NMR (125 MHz, DMSO) δ 181.1, 165.9, 162.4, 158.2, 158.1, 155.1, 130.9, 123.2, 121.7, 115.8, 106.1, 98.7, 93.1, 56.8; LCMS: Mass calculated for C16H12O5, [M+H]+, 285. Found 285.

情報源と証拠