2-Pyrimidinemethanol → N-cyclopropyl-4-methyl-3-{[4-(pyrimidin-2-ylmethoxy)benzoyl]amino}benzamide
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][OH:8].[CH:9]1([NH:12][C:13](=[O:31])[C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([NH:21][C:22](=[O:30])[C:23]3[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=3)[CH:15]=2)[CH2:11][CH2:10]1>>[CH:9]1([NH:12][C:13](=[O:31])[C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([NH:21][C:22](=[O:30])[C:23]3[CH:24]=[CH:25][C:26]([O:8][CH2:7][C:2]4[N:3]=[CH:4][CH:5]=[CH:6][N:1]=4)=[CH:27][CH:28]=3)[CH:15]=2)[CH2:11][CH2:10]1参加物
3
実験手順
The title compound was prepared from 2-pyrimidinemethanol and N-cyclopropyl-3-[(4-hydroxybenzoyl)amino]-4-methylbenzamide according to the method used to prepared Example 8, to give the title compound as a solid (149 mg, 58%); NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.67 (m, 2H), 2.24 (s, 3H), 2.84 (m, 1H), 5.37 (s, 2H), 7.09 (d, 2H), 7.31 (d, 1H), 7.47 (m, 1H), 7.61 (m, 1H), 7.78 (d, 1H), 7.93 (d, 2H), 8.35 (m, 1H), 8.83 (m, 2H), 9.80 (s, 1H); Mass Spectrum: M+H+ 403.
後処理
- customto prepared Example 8