2-Pyrimidinemethanol → HCID 11235035、化合物

HRID 403032

反応式

HRID 403032 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][OH:8].[CH:9]1([NH:12][C:13](=[O:31])[C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([NH:21][C:22](=[O:30])[C:23]3[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=3)[CH:15]=2)[CH2:11][CH2:10]1>>[CH:9]1([NH:12][C:13](=[O:31])[C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([NH:21][C:22](=[O:30])[C:23]3[CH:24]=[CH:25][C:26]([O:8][CH2:7][C:2]4[N:3]=[CH:4][CH:5]=[CH:6][N:1]=4)=[CH:27][CH:28]=3)[CH:15]=2)[CH2:11][CH2:10]1

参加物

3

反応物 2

HCID 27630242-PyrimidinemethanolHCID 66631169N-cyclopropyl-3-[(4-hydroxybenzoyl)amino]-4-methylbenzamide

生成物 1

HCID 11235035HCID 11235035、化合物収率 58%

実験手順

The title compound was prepared from 2-pyrimidinemethanol and N-cyclopropyl-3-[(4-hydroxybenzoyl)amino]-4-methylbenzamide according to the method used to prepared Example 8, to give the title compound as a solid (149 mg, 58%); NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.67 (m, 2H), 2.24 (s, 3H), 2.84 (m, 1H), 5.37 (s, 2H), 7.09 (d, 2H), 7.31 (d, 1H), 7.47 (m, 1H), 7.61 (m, 1H), 7.78 (d, 1H), 7.93 (d, 2H), 8.35 (m, 1H), 8.83 (m, 2H), 9.80 (s, 1H); Mass Spectrum: M+H+ 403.

後処理

  1. customto prepared Example 8

出典と根拠

ORDレコード
ord-57272a25382c416ba62397316f26fe60
出典データセット
uspto-grants-2014_06
特許番号
US08742124B2

関連ノート

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