関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2,4-Dibromo-1,3-thiazole | HCID 2763297 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(4-Bromo-1,3-thiazol-2-yl)morpholine | HCID 43811042 | 68.5% |
反応手順
To a microwave vial was added N,N-diisopropylethylamine (0.86 ml, 4.9 mmol), 2,4-dibromothiazole (1.00 g, 4.1 mmol), and morpholine (0.43 ml, 4.9 mmol) in EtOH (4 mL). The mixture was heated under microwave irradiation at 140° C. for 35 minutes. The reaction mixture was concentrated in vacuo. The crude material was dissolved in minimal DCM/MeOH and purified via MPLC (eluting with 0-30% EtOAc in hexanes) to yield 4-(4-bromothiazol-2-yl)morpholine (0.700 g, 68% yield) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524900B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
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| ORD ID | ord-f5d6627eee1f4de1a5d7c92be3874165 |
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| 出典メモ | uspto-grants-2013_09 |
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