Bromine → 2-Bromo-1-(quinolin-6-yl)ethanone hydrobromide

HRID 40326

反応式

HRID 40326 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](=[O:13])[CH3:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[BrH:14].CC(O)=O.BrBr>>[BrH:14].[Br:14][CH2:12][C:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:1]=[CH:2][CH:3]=[CH:4]2)=[O:13]

参加物

4

反応物 3

HCID 24408BromineHCID 2585591-(Quinolin-6-yl)ethan-1-oneHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

生成物 1

HCID 866302742-Bromo-1-(quinolin-6-yl)ethanone hydrobromide収率 76.3%

実験手順

A 250 mL RB flask was charged with 1-(quinolin-6-yl)ethanone (3.82 g, 22.3 mmol) and 30% HBr/AcOH (45.0 ml). Bromine (1.14 ml, 22.1 mmol) was added slowly. This was stirred at room temperature for 4 hours, at which point full conversion to product (with a small amount of dibrominated side product) was observed. The reaction mixture was filtered and the solid was washed with Et2O to give 2-bromo-1-(quinolin-6-yl)ethanone hydrobromide (5.6359 g, 76.3% yield). The compound was used in the next step without further purification.

後処理

  1. filtrationThe reaction mixture was filtered
  2. washthe solid was washed with Et2O

出典と根拠

ORDレコード
ord-bec1a85677504629888211f7e5002d4e
出典データセット
uspto-grants-2013_09
特許番号
US08524900B2

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