(4-Fluoro-2-methoxyphenyl)boronic acid → 5-(4-Fluoro-2-methoxy-phenyl)-pyridazin-4-ylamine

HRID 403397ノート

反応式

HRID 403397 の反応式
Cl[C:2]1[C:3]([NH2:8])=[CH:4][N:5]=[N:6][CH:7]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13](B(O)O)=[C:12]([O:19][CH3:20])[CH:11]=1>CCCCCCC.C(OCC)(=O)C.CO>[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:2]2[C:3]([NH2:8])=[CH:4][N:5]=[N:6][CH:7]=2)=[C:12]([O:19][CH3:20])[CH:11]=1

参加物

4

反応物 2

HCID 2782672(4-Fluoro-2-methoxyphenyl)boronic acidHCID 130010635-Chloropyridazin-4-amine

生成物 1

HCID 866984845-(4-Fluoro-2-methoxy-phenyl)-pyridazin-4-ylamine

試薬・触媒・溶媒 1

HCID 21266605Heptane ethyl acetate methanol溶媒

実験手順

The title compound was prepared in analogy to example 1, intermediate b, from 5-chloro-pyridazin-4-ylamine (CAS RN 53180-92-0) and 4-fluoro-2-methoxyphenylboronic acid (CAS RN 179899-07-1) and using a gradient of n-heptane:ethyl acetate:methanol (100:0:0 to 0:100:0 to 0:50:50) for the chromatographic purification. Light yellow solid (37%). MS (ESI+): m/z=220.089 ([M+H]+).

後処理

  1. customfor the chromatographic purification

出典と根拠

ORDレコード
ord-61c8ec7455654a7d8882fb91696f3901
出典データセット
uspto-grants-2014_06
特許番号
US08748434B2

反応ノート

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