HCID 178490494、化合物 → HCID 178489873、化合物
反応式
[OH:1][C:2]1[C:7]([NH:8][C:9](=O)[C:10]2[CH:15]=[C:14]([CH3:16])[C:13]([O:17][CH3:18])=[C:12]([CH3:19])[CH:11]=2)=[C:6]([OH:21])[N:5]=[C:4]([S:22][CH3:23])[N:3]=1>P(Cl)(Cl)(Cl)=O>[CH3:18][O:17][C:13]1[C:12]([CH3:19])=[CH:11][C:10]([C:9]2[O:21][C:6]3[N:5]=[C:4]([S:22][CH3:23])[N:3]=[C:2]([OH:1])[C:7]=3[N:8]=2)=[CH:15][C:14]=1[CH3:16]参加物
3
実験手順
10.1 g of N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide in 55 ml of phosphorus oxychloride were heated to 60° C. for 3 h. After cooling, the resulting solid was collected by filtration with suction and washed with methyl tert-butyl ether. The solid was then dissolved in a mixture of dichloromethane and tetrahydrofuran, washed with a saturated aqueous sodium hydrogencarbonate solution, dried and concentrated in vacuo. 5.9 g of the title compound were obtained.
後処理
- temperatureAfter cooling
- filtrationthe resulting solid was collected by filtration with suction