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Trifluoroacetic acid → [4-(5-Cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrim idin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | [4-(5-Cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid tert-butyl ester | HCID 86679898 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [4-(5-Cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrim idin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid | HCID 53311353 | 108.2% |
反応手順
25 mg of [4-(5-cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid tert-butyl ester were dissolved in 2 ml of dichloromethane and treated with 1 nil of trifluoroacetic acid. After 16 h the mixture was concentrated and freeze-dried. 24 mg of the title compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748436B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-f0a4d15b90d148558f23dcb0955982f0 |
| 出典メモ | uspto-grants-2014_06 |