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Triphosgene → (S)-3-isocyanato-2,2-dimethyl-butane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphosgene | HCID 94429 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | (2S)-3,3-dimethylbutan-2-amine | HCID 7004913 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-3-isocyanato-2,2-dimethyl-butane | HCID 12169316 | 90% |
反応手順
To a solution of (S)-1,2,2-trimethylpropylamine (626 mg, 6.2 mmol) in methylene chloride (20 mL) and satd aq NaHCO3 (20 mL) was added triphosgene (607 mg, 2.05 mmol) at 0° C. The mixture was stirred for 15 min. The organic phase was separated, dried and concentrated to give (S)-3-isocyanato-2,2-dimethyl-butane (845 mg, 90%). 1H NMR (CDCl3): 0.90 (s, 9H), 1.21 (m, 3H), 3.31 (m, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748444B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-28eb4bf7a3314f19b7230cd5ea3248b3 |
| 出典メモ | uspto-grants-2014_06 |