Hydrogen Peroxide → HCID 178526288、化合物
反応式
[OH:1]O.[N:3]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1>CC(O)=O>[N+:3]1([O-:1])[C:11]2[CH:10]=[CH:9][CH:8]=[N:7][C:6]=2[NH:5][CH:4]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
Hydrogen peroxide (30 wt % solution in water, 38.0 ml, 372 mmol) was added to a suspension of 3H-imidazo[4,5-b]pyridine (4.93 g, 41.4 mmol) in AcOH (40 mL) at room temperature. The resulting reaction mixture was stirred at 80° C. for 3 h, cooled to RT and concentrated in vacuo to a volume ˜50 mL. Concentration to dryness was done using a stream of N2. The resulting residue was suspended in water (˜10 mL). Filtration afforded the title compound (4.61 g, 82.4% yield).
後処理
- customThe resulting reaction mixture
- temperaturecooled to RT
- concentrationconcentrated in vacuo to a volume ˜50 mL
- concentrationConcentration to dryness
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-e8585171280146ac9eb86621d1c56313
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524900B2
反応ノート
読み込み中…