Ammonia → 4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-ol

HRID 403664ノート

反応式

HRID 403664 の反応式
Cl.C([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[N:12]=[CH:11][N:10]=[C:9]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]#[CH:26])[CH:20]=1)(=O)C.N>CO>[C:25]([C:21]1[CH:20]=[C:19]([NH:18][C:9]2[C:8]3[C:13](=[CH:14][C:15]([O:16][CH3:17])=[C:6]([OH:5])[CH:7]=3)[N:12]=[CH:11][N:10]=2)[CH:24]=[CH:23][CH:22]=1)#[CH:26]

参加物

4

反応物 2

HCID 222AmmoniaHCID 866599184-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride

生成物 1

HCID 219252124-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-ol収率 72%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride (10 g, 0.027 mol), methanol (250 ml) and 25% aqueous ammonia (8 ml, 0.106 mol, 3.93 equiv) was stirred at room temperature for 17 hours and then heated to reflux for 1.5 hours. The mixture was cooled and the precipitate was formed and isolated and dried to give 5.66 g product. MS (ESI) m/z: 307 (M+1).

後処理

  1. temperatureheated
  2. temperatureto reflux for 1.5 hours
  3. temperatureThe mixture was cooled
  4. customthe precipitate was formed
  5. customisolated
  6. customdried

出典と根拠

ORDレコード
ord-2c03765ed6134140a1c048dfeb4a9b7d
出典データセット
uspto-grants-2014_06
特許番号
US08748453B2

反応ノート

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