Diphenyl Ether → 7-Bromo-1,5-naphthyridin-4-ol

HRID 40370ノート

反応式

HRID 40370 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([NH:8][CH:9]=[C:10]2[C:15](=[O:16])OC(C)(C)OC2=O)[CH:5]=[N:6][CH:7]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:15](=[O:16])[CH:10]=[CH:9][NH:8]2)=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 7583Diphenyl EtherHCID 675027485-((5-Bromopyridin-3-ylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

生成物 1

HCID 134591367-Bromo-1,5-naphthyridin-4-ol収率 84%

反応条件

温度
250 °C

実験手順

A 500 mL round bottom flask equipped with a reflux condenser was charged with 5-((5-bromopyridin-3-ylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (10.5 g, 32.1 mmol) and diphenyl ether (84.5 mL, 32.1 mmol). This was heated to 250° C. in heating mantle and allowed to stay at this temperature for 1 hour. Reaction mixture was cooled to room temperature and diluted with 300 mL of Hexanes. This was heated to 60° C. and triturated in this system for 3 hrs to afford 7-bromo-1,5-naphthyridin-4(1H)-one (6.05 g, 84% yield) as a crude brown solid. This was used without further purification. MS[M+H]=227.0. Calc'd for C8H5BrN2O=225.0.

後処理

  1. customA 500 mL round bottom flask equipped with a reflux condenser
  2. temperaturein heating mantle
  3. customReaction mixture
  4. temperaturewas cooled to room temperature
  5. temperatureThis was heated to 60° C.
  6. customtriturated in this system for 3 hrs

出典と根拠

ORDレコード
ord-446bf2fdbbe04251977a1db310bcacb9
出典データセット
uspto-grants-2013_09
特許番号
US08524900B2

反応ノート

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