(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → (S)-3-Methyl-2-(1-oxo-6-(4-(3-m-tolylureido)phenyl)isoindolin-2-yl)butanoic acid

HRID 403709ノート

反応式

HRID 403709 の反応式
FC1C=CC(NC(=O)NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=CC=2)=CC=1.[CH3:35][CH:36]([CH3:69])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][C:46]([C:51]3[CH:56]=[CH:55][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:62]=[C:63]([CH3:67])[CH:64]=[CH:65][CH:66]=4)=[O:59])=[CH:53][CH:52]=3)=[CH:47][CH:48]=2)[C:43]1=[O:68])[C:38]([O:40]C)=[O:39]>>[CH3:35][CH:36]([CH3:69])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][C:46]([C:51]3[CH:52]=[CH:53][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:62]=[C:63]([CH3:67])[CH:64]=[CH:65][CH:66]=4)=[O:59])=[CH:55][CH:56]=3)=[CH:47][CH:48]=2)[C:43]1=[O:68])[C:38]([OH:40])=[O:39]

参加物

3

反応物 2

HCID 53303121(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acidHCID 131731444(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(3-m-tolylureido)phenyl)isoindolin-2-yl)butanoate

生成物 1

HCID 67307023(S)-3-Methyl-2-(1-oxo-6-(4-(3-m-tolylureido)phenyl)isoindolin-2-yl)butanoic acid収率 85%

実験手順

The compound of example 22 was prepared analogous to compound of example 8 by hydrolysis of compound of example 21.

出典と根拠

ORDレコード
ord-91220c928f9c49d7a269d0e716597efb
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

反応ノート

読み込み中…