(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(3-p-tolylthioureido)phenyl)isoindolin-2-yl)butanoate → (S)-3-Methyl-2-(1-oxo-6-(4-(3-p-tolylthioureido)phenyl)isoindolin-2-yl)butanoic acid

HRID 403737ノート

反応式

HRID 403737 の反応式
FC1C=CC=CC=1NC(=S)NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1.[CH3:35][CH:36]([CH3:69])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][C:46]([C:51]3[CH:56]=[CH:55][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:66]=[CH:65][C:64]([CH3:67])=[CH:63][CH:62]=4)=[S:59])=[CH:53][CH:52]=3)=[CH:47][CH:48]=2)[C:43]1=[O:68])[C:38]([O:40]C)=[O:39]>>[CH3:35][CH:36]([CH3:69])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][C:46]([C:51]3[CH:56]=[CH:55][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:62]=[CH:63][C:64]([CH3:67])=[CH:65][CH:66]=4)=[S:59])=[CH:53][CH:52]=3)=[CH:47][CH:48]=2)[C:43]1=[O:68])[C:38]([OH:40])=[O:39]

参加物

3

反応物 2

HCID 53303392(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(3-p-tolylthioureido)phenyl)isoindolin-2-yl)butanoateHCID 87349957(S)-2-(6-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

生成物 1

HCID 87349995(S)-3-Methyl-2-(1-oxo-6-(4-(3-p-tolylthioureido)phenyl)isoindolin-2-yl)butanoic acid収率 83%

実験手順

The compound of example 54 was prepared analogous to compound of example 52 by hydrolysis of compound of example 53.

出典と根拠

ORDレコード
ord-aaa5c5fee40e41e183294b4d071bf845
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

反応ノート

読み込み中…