3-Fluorophenyl isothiocyanate → (S)-Methyl 2-(6-(4-(3-(3-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403738

反応式

HRID 403738 の反応式
FC1C=CC=CC=1[NH:8][C:9](=[S:35])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:25]=[C:24]3[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[C:23]3=[O:26])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[F:61][C:62]1[CH:63]=[C:64](N=C=S)[CH:65]=[CH:66][CH:67]=1>>[F:61][C:62]1[CH:67]=[C:66]([NH:8][C:9](=[S:35])[NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:25]=[C:24]4[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:33])[CH3:34])[C:28]([O:30][CH3:31])=[O:29])[C:23]4=[O:26])=[CH:19][CH:18]=3)=[CH:15][CH:16]=2)[CH:65]=[CH:64][CH:63]=1

参加物

4

反応物 3

HCID 98343-Fluorophenyl isothiocyanateHCID 53303391(S)-Methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

生成物 1

HCID 131731451(S)-Methyl 2-(6-(4-(3-(3-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

実験手順

The compound of example 55 was prepared analogous to compound of example 51 by reaction of compound of example 6 with 3-fluorophenyl isothiocyanate. The compound of example 55 was used directly without isolation for the preparation of compound of example 56.

出典と根拠

ORDレコード
ord-27fd5ebf11be44aaaf0465285958601c
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

関連ノート

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