Hydrochloric Acid → (S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

関与物質

反応手順

The compound of example 97 (130 mg, 0.294 mmol) was taken in THF (4 mL) and MeOH (1 mL). To this reaction mixture, 1 N LiOH (61.89 mg, 1.475 mmol) was added and stirred at room temperature for 2-3 h. After completion of the reaction, the solvent was evaporated and the residue obtained was dissolved in water and acidified with 1 N HCl to obtain the title compound, which was filtered and dried.

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