Alanine methyl ester hydrochloride → (S)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)propanoate

反応式

[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@H:12]([CH:17](C)C)[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.COC(=O)[C@H](C)N>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@@H:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 2733257Alanine methyl ester hydrochloride

HCID 131731530(R)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

生成物 1

HCID 125486231(S)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)propanoate

実験手順

The compound of example 335 was prepared analogous to compound of example 329 by reaction of the compound of example 328 and L-alanine methyl ester hydrochloride.

出典と根拠

ORDレコード: ord-b0490ab00d83423f8000ab11a76cf2d4
出典データセット: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08748426B2

反応ノート

読み込み中…