Glycine methyl ester hydrochloride → Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)acetate

HRID 403957

反応式

HRID 403957 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12](C(C)C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.BrC1C=CC(C(OC)=O)=C(CBr)C=1.Cl.COC(=O)CN>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH2:5]2

参加物

4

反応物 3

HCID 122755Glycine methyl ester hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

生成物 1

HCID 67306590Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)acetate

実験手順

The compound of example 362 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and glycine methyl ester hydrochloride.

出典と根拠

ORDレコード
ord-41224919cf1642cbaf6ef71f7d08f0a8
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

関連ノート

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