Alanine methyl ester hydrochloride → (S)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)propanoate

HRID 403960

反応式

HRID 403960 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12]([CH:17](C)C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.BrC1C=CC(C(OC)=O)=C(CBr)C=1.Cl.COC(=O)[C@H](C)N>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@@H:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2

参加物

4

反応物 3

HCID 2733257Alanine methyl ester hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

生成物 1

HCID 131731537(S)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)propanoate

実験手順

The compound of example 365 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and alanine methyl ester hydrochloride.

出典と根拠

ORDレコード
ord-b9f5814b6d2345f185e617cff9c4cf2f
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

関連ノート

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