(R)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acid → (S)-2-(1-Oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetic acid

HRID 403968ノート

反応式

HRID 403968 の反応式
CC(C)[C@@H](N1CC2C(=CC=C(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)C=2)C1=O)C(O)=O.[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:67])([F:66])[F:65])[CH:59]=4)=[O:56])=[CH:50][CH:49]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[C@@H:68]([C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)[C:69]([O:71]C)=[O:70]>>[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:66])([F:65])[F:67])[CH:59]=4)=[O:56])=[CH:50][CH:49]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[C@@H:68]([C:73]1[CH:74]=[CH:75][CH:76]=[CH:77][CH:78]=1)[C:69]([OH:71])=[O:70]

参加物

3

反応物 2

HCID 67308300(R)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acidHCID 131731539(S)-Methyl 2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetate

生成物 1

HCID 67307590(S)-2-(1-Oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetic acid収率 92%

実験手順

The compound of example 373 was prepared analogous to the compound of example 361 by hydrolysis of the compound of example 372.

出典と根拠

ORDレコード
ord-23e60da0b99a49ca9718658c996ad190
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

反応ノート

読み込み中…