(S)-Methyl 2-(6-(5-(3-(3,4-difluorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate → (S)-2-(6-(5-(3-(3,4-Difluorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

関与物質

役割	名称	HCID	仕込み量
反応物	(S)-Methyl 2-(6-(5-(3-(3,4-difluorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 67323403	—
反応物	(S)-2-(6-(5-(3-(2-Chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 70975553	—
生成物	(S)-2-(6-(5-(3-(3,4-Difluorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 70975257	86%

The compound of example 400 was prepared analogous to the compound of example 394 by hydrolysis of the compound of example 399.