化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromo-5-nitrobenzotrifluoride → (S)-Methyl 3-methyl-2-(6-(4-nitro-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-5-nitrobenzotrifluoride | HCID 136198 | — |
| 反応物 | (S)-Methyl 3-methyl-2-(1-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-2-yl)butanoate | HCID 123866646 | — |
| 反応物 | (S)-Methyl 3-methyl-2-(6-(5-nitropyridin-2-yl)-1-oxoisoindolin-2-yl)butanoate | HCID 131731547 | — |
| 触媒 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-Methyl 3-methyl-2-(6-(4-nitro-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)butanoate | HCID 131731555 | 85% |
反応手順
The compound of example 413 was prepared analogous to the compound of example 391 by reaction of the compound of example 390, 1-bromo-4-nitro-2-(trifluoromethyl)benzene and Pd(dppf)Cl2: CH2Cl2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748426B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-b122e9793f8247198e3c59a167f592bd |
| 出典メモ | uspto-grants-2014_06 |