Methyl 4-(1-cyano-1-methylethyl)benzoate → HCID 131731591、化合物

HRID 404103ノート

反応式

HRID 404103 の反応式
[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](C4SC(C5C=CC=CC=5)=CN=4)=[O:25])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5].NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[C:64]([C:66]([C:69]1[CH:78]=[CH:77][C:72](C(OC)=O)=[CH:71][CH:70]=1)([CH3:68])[CH3:67])#[N:65]>>[C:64]([C:66]([C:69]1[CH:78]=[CH:77][C:72]([C:24]([NH:23][C:20]2[CH:19]=[CH:18][C:17]([C:12]3[CH:11]=[C:10]4[C:15]([CH2:16][N:8]([C@@H:3]([CH:2]([CH3:1])[CH3:38])[C:4]([O:6][CH3:7])=[O:5])[C:9]4=[O:37])=[CH:14][CH:13]=3)=[CH:22][CH:21]=2)=[O:25])=[CH:71][CH:70]=1)([CH3:68])[CH3:67])#[N:65]

参加物

4

反応物 3

HCID 14698604Methyl 4-(1-cyano-1-methylethyl)benzoateHCID 123332092(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenylthiazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

生成物 1

HCID 131731591HCID 131731591、化合物収率 58%

実験手順

The compound of example 630B was prepared analogous to the compound of example 611 by reaction of compound of example 6 with compound of example 630A.

出典と根拠

ORDレコード
ord-2489208ae1424ae1ad4af2eddc82e049
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

反応ノート

読み込み中…