Potassium Cyanide → Methyl 5-cyanopentanoate

HRID 40428

反応式

HRID 40428 の反応式
[C-:1]#[N:2].[K+].Br[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10]>O.CO>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])#[N:2]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 79557Methyl 5-bromovalerate

生成物 1

HCID 554130Methyl 5-cyanopentanoate収率 74.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Potassium Cyanide (4 g, 61.44 mmol) is dissolved in 70 mL water and 200 mL methanol. To the solution 10 g (51.2 mmol) of methyl 5-bromopentanoate is added and the mixture is refluxed overnight. The reaction mixture is concentrated to dryness. To the residue, 100 mL of EtOAc is added to extract the product. The organic is washed with water three times, dried and concentrated to yield 5.37 g (74%) of methyl 5-cyanopentanoate as an oil.

後処理

  1. temperaturethe mixture is refluxed overnight
  2. concentrationThe reaction mixture is concentrated to dryness
  3. additionTo the residue, 100 mL of EtOAc is added
  4. extractionto extract the product
  5. washThe organic is washed with water three times
  6. customdried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-6793678113e5437799565c1d49dd7856
出典データセット
uspto-grants-2013_09
特許番号
US08529882B2

関連ノート

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