Triethylamine → ((2S,5R)-1-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(4-nitrophenyl)-1,3,5-triazin-2-yl)pyrrolidine-2,5-diyl)dimethanol

HRID 404483

反応式

HRID 404483 の反応式
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[N:5]=[C:4]([N:17]2[C@@H:21]([CH2:22][OH:23])[CH2:20][CH2:19][C@H:18]2[CH2:24][OH:25])[N:3]=1.Cl.[CH:27]12[NH:34][CH:31]([CH2:32][CH2:33]1)[CH2:30][O:29][CH2:28]2.C(N(CC)CC)C>C(O)C>[CH:31]12[N:34]([C:2]3[N:7]=[C:6]([C:8]4[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=4)[N:5]=[C:4]([N:17]4[C@@H:21]([CH2:22][OH:23])[CH2:20][CH2:19][C@H:18]4[CH2:24][OH:25])[N:3]=3)[CH:27]([CH2:33][CH2:32]1)[CH2:28][O:29][CH2:30]2

参加物

5

反応物 3

HCID 8471TriethylamineHCID 534011293-Oxa-8-azabicyclo(3.2.1)octane hydrochlorideHCID 86636521HCID 86636521、化合物

生成物 1

HCID 67021926((2S,5R)-1-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(4-nitrophenyl)-1,3,5-triazin-2-yl)pyrrolidine-2,5-diyl)dimethanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
130 °C

実験手順

A suspension of ((2S,5R)-1-(4-chloro-6-(4-nitrophenyl)-1,3,5-triazin-2-yl)pyrrolidine-2,5-diyl)dimethanol (0.91 g, 2.5 mmol), 3-oxa-8-azabicyclo[3.2.1]octane hydrochloride (0.37 g, 2.5 mmol) in ethanol (13 mL) was treated with triethylamine (1 mL) and heated in a microwave reactor for 20 minutes at 130° C. The reaction mixture was purified by automated flash chromatography (methanol/chloroform) to provide the title compound as a hard peach colored foam. MS (ES+)=443.2 (M+H)+

後処理

  1. customThe reaction mixture was purified by automated flash chromatography (methanol/chloroform)

出典と根拠

ORDレコード
ord-f3f5d48c603d42f0b930208d09982b2a
出典データセット
uspto-grants-2014_06
特許番号
US08748421B2

関連ノート

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